ALPN-101 is distinct from the other biologic therapies and superior to combination biological blockade
Preclinical activity suggests unique effectiveness across a range of rheumatic and other inflammatory diseases
SEATTLE–(BUSINESS WIRE)– Alpine Immune Sciences, Inc. (NASDAQ:ALPN), a leading clinical-stage immunotherapy company focused on developing innovative treatments for cancer, autoimmune/inflammatory, and other diseases, presented new preclinical data on ALPN-101, a first-in-class dual CD28/ICOS antagonist for the treatment of autoimmune/inflammatory diseases, at the 2019 American College of Rheumatology Annual Meeting (ACR) in Atlanta, GA.
ALPN-101 is designed to inhibit two key costimulatory pathways that regulate disease-relevant, pathogenic T and B lymphocytes. The new data demonstrate a unique potency of ALPN-101, often superior even to combinations of biologics individually targeting the CD28 and ICOS pathways, as measured by in vitro assays involving patient-derived immune cells and in vivo mouse models of inflammatory arthritis, lupus, and Sjögren’s Syndrome.
The data were presented in two posters:
1531. ALPN-101, a First-in-Class Dual ICOS/CD28 Antagonist, Suppresses Key Effector Mechanisms Underlying Rheumatoid and Psoriatic Arthritis
2416: ALPN-101, a First-in-Class Dual ICOS/CD28 Antagonist, Suppresses Key Effector Mechanisms Associated with Sjögren’s Syndrome and Systemic Lupus Erythematosus
“Particularly intriguing are the unique inflammatory pathways that appear to be affected by ALPN-101, distinct from the other biologic therapies studied, as well as its potent efficacy in the animal models,” commented Stanford Peng, M.D., Ph.D., President and Head of Research and Development at Alpine. “Such observations are especially timely as we are presently completing our Phase I study and are considering a number of different Phase II options. With these new data, future development options expand to include Sjögren’s Syndrome and Systemic Lupus Erythematosus.”
Both full poster presentations can be found in the autoimmune/inflammation pipeline section of the alpineimmunesciences.com website.
ALPN-101 is a novel Fc fusion protein of a human inducible T cell costimulator ligand (ICOSL) variant immunoglobulin domain (vIgD™), and a first-in-class therapeutic designed to inhibit simultaneously the CD28 and ICOS inflammation pathways. CD28 and ICOS are closely related costimulatory molecules with partially overlapping roles in T cell activation likely connected to multiple autoimmune and inflammatory diseases. In preclinical models of graft versus host disease, inflammatory arthritis, connective tissue disease and multiple sclerosis, ALPN-101 demonstrates efficacy superior to blockade of the CD28 or ICOS pathways alone.
About Alpine Immune Sciences
Alpine Immune Sciences, Inc. is committed to leading a new wave of immune therapeutics, creating potentially powerful multifunctional immunotherapies to improve patients’ lives via unique protein engineering technologies. Alpine has two lead programs. The first, ALPN-101 for autoimmune/inflammatory diseases, is a selective dual T-cell costimulation blocker engineered to reduce pathogenic T and B cell immune responses by blocking ICOS and CD28. The second, ALPN-202 for cancer, is a conditional CD28 costimulator and dual checkpoint inhibitor. Alpine is backed by world-class research and development capabilities, a highly-productive scientific platform, and a proven management team. For more information, visit www.alpineimmunesciences.com.
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Source: Alpine Immune Sciences, Inc.