NEW YORK, May 30, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:
DNA Sequencing: Emerging Technologies and Applications
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INTRODUCTION
STUDY OBJECTIVES
BCC's goal in conducting this study is to provide an overview of the current and future characteristics of the global market for industrial enzymes. The key objective is to present a comprehensive analysis of the current market and its future direction in the enzymes market as an important tool for increasing the efficiency and specificity of the products in which the enzymes are used.
This report is an update to the previous report on industrial enzymes and explores the present and future strategies within the industrial enzymes market, which includes the detergent, technical, food and beverages, and animal feed sectors. The improvisation of the market, the setbacks and the needs of the market are discussed in this report. The comparisons, usage, and the advantages and disadvantages of types of enzymes are also portrayed in this report.
A detailed analysis of the enzymes industry structure has been conducted. Revenues are broken down by region. Sales figures are estimated for the five-year period from 2011 through 2016.
Applications for industrial enzymes are also discussed separately in the report, with emphasis of the use in technical enzymes and the food and beverages enzymes. The report also covers significant patents and their allotments in each category.
REASONS FOR DOING THIS STUDY
With an increase in the use of enzymes, enzyme usage is completely justifiable because they are natural and biodegradable. By using biodegradable enzymes as substitutes in the place of chemical-based products, the manufacturing process is being redeveloped into a more environmentally friendly process, with less corrosive conditions. Enzyme compatibility with the environment in addition to their ability to increase process efficiency and provide product specificity has enhanced the enzymes market globally.
R&D spending, along with increasing competition, patent expiries and new technologies, are directing this in a new direction. The industry took a leap in 2010 with new advancements and the need for cost reductions. This study looks at almost all the systems affected by various factors.
Acquisition strategies and collaborations by companies are also covered in this report. This study also discusses the strength and weaknesses of each type/ technology in light of new technologies, growing competition and changing customer needs.
INTENDED AUDIENCE
This study contributes to the areas of market growth in food and beverages, animal feed, detergents, leather, and other technical enzyme manufacturers and users. Chemical, biochemical and biotechnical companies and industries, and research institutes will find this study to be of interest.
SCOPE OF THE STUDY
The scope of this study encompasses the industrial enzymes, bio-technical, chemical and biotechnology markets. BCC analyzes each market and its applications, regulatory environment, technology involved, market projections and market share. Technological issues include the latest trends and developments.
METHODOLOGY
BCC conducted a comprehensive literature search, which included technical newsletters and journals, and many other sources. Data were collected through interviews and correspondence with various chemical, biotechnical, food and beverages, and technical experts. Projections were based on estimates such as the current number of end users, potential end users, mergers and acquisitions, and market trends.
INFORMATION SOURCES
Many companies within the industry were surveyed to obtain data for this study. Included were manufacturers and end users of enzymes in the chemical, biotechnology, food and beverages, leather, and detergent industries. Data were gathered from various industry sources. BCC spoke with officials within the industry, consulted newsletters, company literature, product literature and a host of technical articles, journals, indexes and abstracts. Exhaustive investigations of databases by key terminology were completed. In addition, data were compiled from current financial, trade and government sources.
ABOUT THE AUTHOR
The study has been carried out by a team of professionals in the biotechnology industry. The project manager for this project is Shalini S. Dewan, who holds a master's degree in pharmaceutical chemistry and has over 14 years of industry experience. Among the research topics she has covered are studies on compounds of potential pharmaceutical interest from ibuprofen and 2-naphthyl acetic acid. Shalini was awarded a Gold Medal by the Prime Minister of India for her work and has worked with top companies in India and in the U.S. Some of her other reports with BCC are Reagents for Chromatography; Spectroscopy, An Enduring Market; Advanced Drug Delivery Systems: Technologies and Global Markets; Orthopedic Drugs, Implants and Devices; Medical Imaging Reagents and Analysis Equipment; Pharmaceutical Regulatory Industry; The Dynamic Media, Sera and Reagent Market in Biotechnology; Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets; Chiral Technology: Global Markets; Autacoids and Related Drugs: Technologies and Global Markets; Contraceptives: Technologies and Global Markets; Liver Disease Treatments: The Global Market; Hormone Replacement Therapies and Other Hormone Therapies: Global Markets; Cardiovascular Medicine: Diagnostics, Drugs and Devices; and Cancer Therapies: Technologies and Global Markets.
TABLE OF CONTENTS
CHAPTER ONE: INTRODUCTION 1
STUDY GOALS AND OBJECTIVES 1
REASONS FOR DOING THE STUDY 1
INTENDED AUDIENCE 2
SCOPE AND FORMAT 3
METHODOLOGY 3
INFORMATION SOURCES 4
RELATED BCC REPORTS 4
ANALYST CREDENTIALS 4
BCC ON-LINE SERVICES 4
DISCLAIMER 5
CHAPTER TWO: EXECUTIVE SUMMARY 6
SUMMARY TABLE GLOBAL VALUE OF SEQUENCING PRODUCTS
AND SERVICES BY TYPE, THROUGH 2016 ($ MILLIONS) 6
SUMMARY FIGURE GLOBAL VALUE OF SEQUENCING PRODUCTS
AND SERVICES BY TYPE, 2010-2016 ($ MILLIONS) 7
EXECUTIVE SUMMARY (CONTINUED) 8
CHAPTER THREE: OVERVIEW 9
INTRODUCTION 9
TABLE 1 SCOPE OF THIS REPORT 9
SEQUENCING INDUSTRY MARKET 10
TABLE 2 GLOBAL VALUE OF THE SEQUENCING MARKET BY
PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 10
SEQUENCING INDUSTRY GROWTH DRIVING FORCES 11
TABLE 3 KEY GROWTH DRIVING FORCES IN THE DNA
SEQUENCING MARKET 11
SEQUENCING PRODUCTS 12
SEQUENCING INSTRUMENTS AND CONSUMABLES 12
SAMPLE PREPARATION REAGENTS AND KITS 13
BIOINFORMATICS 13
SEQUENCING SERVICES 13
SEQUENCING PRODUCT LIFE CYCLE STATUS 14
TABLE 4 LIFE CYCLE OF DNA SEQUENCING TECHNOLOGIES 14
SEQUENCING INDUSTRY 15
TABLE 5 SEQUENCING INSTRUMENT COMPETITORS BY
TECHNOLOGY 15
TABLE 5 (CONTINUED) 16
CHAPTER FOUR: DNA SEQUENCING TECHNOLOGY 17
INTRODUCTION 17
FIGURE 1 CENTRAL MOLECULAR BIOLOGY DOGMA 17
GENOMIC VARIATION 18
TABLE 6 TYPES OF HUMAN GENOME VARIATIONS 18
FIGURE 2 DNA, MRNA, AND GENETIC VARIATION 19
DNA SEQUENCING ANALYSIS 20
TABLE 7 DNA SEQUENCING METHODS 21
HISTORY OF DNA SEQUENCING 21
TABLE 8 DNA SEQUENCING HISTORICAL TIMELINE 21
TABLE 8 (CONTINUED) 22
HISTORY OF DNA SEQUENCING (CONTINUED) 23
HISTORY OF DNA SEQUENCING (CONTINUED) 24
HISTORY OF DNA SEQUENCING (CONTINUED) 25
HISTORY OF DNA SEQUENCING (CONTINUED) 26
FIGURE 3 SEQUENCING COST TREND, BASE PAIRS SEQUENCED
PER DOLLAR 27
FIGURE 4 SEQUENCING INSTRUMENT THROUGHPUT TREND,
BASE PAIRS PER DAY 28
FIGURE 5 HUMAN GENOME SEQUENCING COST TREND 29
FIGURE 6 $1,000 GENOME PRODUCT SPACE 30
DNA SEQUENCING WORKFLOW 31
TABLE 9 DNA SEQUENCING WORKFLOW 31
TARGETING TECHNOLOGIES 32
TABLE 10 CHEMICAL TARGETING TECHNOLOGIES 33
DNA SEQUENCING TECHNOLOGIES 34
TABLE 11 DNA SEQUENCING TECHNOLOGIES 34
NEXT-GENERATION SEQUENCING TECHNOLOGIES 35
TABLE 12 NEXT-GENERATION SEQUENCING TECHNOLOGIES 35
Reversible Termination (Illumina Genome Analyzer and
HiSeq) 35
Pyrosequencing (Roche-454) 36
Sequencing by Ligation (Life Technologies) 37
EMERGING SEQUENCING TECHNOLOGIES 37
TABLE 13 EMERGING SEQUENCING TECHNOLOGIES 38
BENCHTOP SEQUENCERS 39
TABLE 14 BENCHTOP SEQUENCING TECHNOLOGIES 39
SEQUENCING INSTRUMENT PERFORMANCE METRICS 40
TABLE 15 SEQUENCING PLATFORM THROUGHPUT
PERFORMANCE 40
TABLE 16 SEQUENCING PLATFORM ACCURACY PERFORMANCE 41
TABLE 17 SEQUENCING INSTRUMENT COST 42
SEQUENCING INSTRUMENT SUMMARY 42
TABLE 18 SEQUENCING INSTRUMENT SUMMARY 43
BIOINFORMATICS TECHNOLOGIES 44
TABLE 19 NGS SEQUENCING BIOINFORMATICS WORKFLOW 44
Base Calling 45
Mapping to a Reference Sequence 46
TABLE 20 SEQUENCE ANNOTATION TYPES 47
Variant Analysis 47
SEQUENCING PRODUCT LIFE CYCLE 48
TABLE 21 LIFE CYCLE OF DNA SEQUENCING TECHNOLOGIES 49
SEQUENCING INSTRUMENT CUMULATIVE INSTALLED BASE 49
FIGURE 7 GLOBAL CUMULATIVE INSTALLED BASE OF DNA
SEQUENCERS, THROUGH JANUARY 2012 50
CHAPTER FIVE: DNA SEQUENCING APPLICATIONS 51
INTRODUCTION 51
FIGURE 8 WHOLE-GENOME SEQUENCING PROJECTS FOR
PROKARYOTES AND EUKARYOTES, APRIL 2010 AND DECEMBER
2011 51
FIGURE 8 (CONTINUED) 52
GENETIC ANALYSIS 53
TABLE 22 GENETIC ANALYSIS FORMATS COMPARISON 54
TABLE 23 SEQUENCING ANALYSIS APPLICATIONS 55
TABLE 23 (CONTINUED) 56
TABLE 24 DE NOVO VERSUS RESEQUENCING REQUIREMENTS 56
DE NOVO WHOLE GENOME SEQUENCING 57
TABLE 25 ESTIMATED NUMBER OF SPECIES ON EARTH AND
PERCENTAGE SEQUENCED, DECEMBER 2011 58
RESEQUENCING 59
Whole-Genome Resequencing 59
FIGURE 9 DISEASE-CAUSING ALLELES AT MAF5 AND MAF1 60
TABLE 26 SINGLE SEQUENCER: WHOLE-GENOME THROUGHPUT
TRENDS, 1975-2011 61
Targeted Resequencing 62
SEQ-BASED METHODS 63
TABLE 27 GENETIC ANALYSIS APPLICATIONS IN WHICH
SEQUENCING COMPETES WITH MICROARRAYS 63
ChIPSeq 64
TABLE 28 COMPARISON OF SEQUENCING WITH MICROARRAYS
FOR CHIP APPLICATIONS 64
DNase-Seq 65
Gene Expression Analysis 65
TABLE 29 COMPARISON OF SEQUENCING AND MICROARRAYS
FOR GENE EXPRESSION ANALYSIS 65
Gene Expression ... (Continued) 66
MethylSeq 67
STRUCTURAL VARIATION STUDIES 67
COMPLEMENTARY SEQUENCING AND MICROARRAY
PLATFORMS 68
SEQUENCING END-USE APPLICATIONS 69
RESEARCH, DRUG DISCOVERY AND DEVELOPMENT 69
Research, Drug Discovery ... (Continued) 70
TABLE 30 PHARMACEUTICAL/DIAGNOSTICS SEQUENCING
PARTNERS 71
Research, Drug Discovery ... (Continued) 72
CLINICAL SEQUENCING 73
TABLE 31 SEQUENCING APPLICATIONS IN CLINICAL
DIAGNOSTICS 73
Clinical Sequencing (Continued) 74
Clinical Sequencing (Continued) 75
TABLE 32 HPV DIAGNOSTICS COMPETITORS 76
CONSUMER SEQUENCING 77
FIGURE 10 GENETIC ANALYSIS COST AND INFORMATION
CONTENT TRENDS (BP/$) 78
Consumer Sequencing (Continued) 79
AGRICULTURAL SEQUENCING 80
TABLE 33 SEQUENCING IMPACT ON AGRICULTURAL PRODUCT
CLASSES 80
MICROBIAL SEQUENCING 81
TABLE 34 KEY APPLICATIONS IN MICROBIAL SEQUENCING 82
FORENSICS SEQUENCING 83
TABLE 35 KEY APPLICATIONS IN FORENSICS AND HUMAN
IDENTITY SEQUENCING 83
CHAPTER SIX: DNA SEQUENCING INITIATIVES 84
FIGURE 11 NIH FUNDING AWARDS FOR DNA SEQUENCINGRELATED
BY INSTITUTE, 2010-2011 85
FIGURE 11 (CONTINUED) 86
FIGURE 12 NIH FUNDING FOR DNA SEQUENCING-RELATED
PROJECTS, 2000-2001 AND 2010-2011 87
NHGRI $1,000 GENOME PROJECT FUNDING 87
TABLE 36 NHGRI GRANTS UNDER THE $1,000 GENOME PROGRAM,
FISCAL YEAR 2009-2011 ($ MILLIONS) 88
SEQUENCING-RELATED GENOMICS PROJECTS 89
TABLE 37 IMPORTANT SEQUENCING RESEARCH INITIATIVES 89
TABLE 37 (CONTINUED) 90
TABLE 37 (CONTINUED) 91
GENOME SEQUENCING PROJECTS 92
Personal Genome Project 92
Archon X Prize in Genomics 92
Genomes 10K Project 93
1,000 Plant and Animal Reference Project 93
MEDICAL SEQUENCING PROJECTS 94
Exome Sequencing of Mendelian Disorders 94
Allelic Spectrum in Common Disease Program 95
Clinseq Project 95
CANCER SEQUENCING PROJECTS 95
International Cancer Genome Consortium 96
Cancer Genome Atlas 96
Tumor Sequencing Project 97
Cancer Genome Project 97
Genomics of Drug Sensitivity in Cancer 98
Catalogue of Somatic Mutations in Cancer 98
Genomics Initiative 99
MICROBIAL SEQUENCING PROJECTS 99
Human Microbiome Project 99
Microbial Genome Sequencing Project 100
Marine Microbial Genome Sequencing Project 100
Fungal Genome Initiative 101
Pathogen Sequencing Program 101
Genomic Encyclopedia of Bacteria and Archaea 101
Metagenomics of the Human Intestinal Tract 102
10,000 Microbial Genomes Project 103
Earth Microbiome Project 103
GENOME VARIATION PROJECTS 103
Encyclopedia of DNA Elements 103
Genomics of Gene Regulation Project 104
1,000 Genomes Project 104
1,000 Plant and Animal Genomes Project 105
Yanhuang Project 105
AGRICULTURAL GENOMICS PROJECTS 106
National Plant Genome Initiative 106
Africa Orphan Crops Consortium 106
IMPACT OF SEQUENCING PROJECTS 106
FIGURE 13 GROWTH IN BASE PAIRS DEPOSITED IN GENBANK,
1988-2011 (BILLIONS) 107
CHAPTER SEVEN: DNA SEQUENCING INDUSTRY STRUCTURE 108
OVERVIEW 108
TABLE 38 DNA SEQUENCING INDUSTRY TRANSITION 108
TABLE 39 DNA SEQUENCING INDUSTRY TRANSITION 109
INDUSTRY STRUCTURE ANALYSIS 109
FIGURE 14 DNA SEQUENCING INDUSTRY STRUCTURE, 1995-2005 110
INDUSTRY STRUCTURE ANALYSIS (CONTINUED) 111
FIGURE 15 DNA SEQUENCING INDUSTRY STRUCTURE, POST-2005 112
SEQUENCING INSTRUMENT AND CONSUMABLES INDUSTRY 113
SEQUENCING INSTRUMENT INDUSTRY 113
TABLE 40 SEQUENCING INSTRUMENT COMPETITORS BY
TECHNOLOGY 114
Sequencing Instrument ... (Continued) 115
NGS INSTRUMENT COMPETITOR MARKET SHARES 116
FIGURE 16 NGS INSTRUMENT COMPETITOR MARKET SHARE, 2011
(%) 116
FIGURE 16 (CONTINUED) 117
FIGURE 17 NGS HIGH-THROUGHPUT INSTRUMENT COMPETITOR
MARKET SHARE, 2011 (%) 118
FIGURE 18 NGS BENCHTOP INSTRUMENT COMPETITOR MARKET
SHARE, 2011 (%) 119
EMERGING SEQUENCING INDUSTRY 120
TABLE 41 EMERGING SEQUENCING INDUSTRY 120
TABLE 42 NANOPORE SEQUENCING INDUSTRY 121
TABLE 43 POTENTIAL BENEFITS OF NANOPORE SEQUENCING 122
DNA SEQUENCING END USERS 122
TABLE 44 DNA SEQUENCING END-USER MARKET SEGMENTS 123
Major Sequencing Centers 123
TABLE 45 TOP 10 NGS INSTRUMENT INSTALLATIONS BY MAJOR
SEQUENCING CENTER, DECEMBER 2011 124
FIGURE 19 MAJOR SEQUENCING CENTER'S SHARE OF THE
GENOME SEQUENCING PROJECTS MARKET BY NUMBER OF
SEQUENCING PROJECTS, DECEMBER 2011 (%) 125
FIGURE 20 BGI ADOPTION OF NEXT-GENERATION SEQUENCERS,
2008 AND 2011 126
FIGURE 20 (CONTINUED) 127
Large-Core Sequencing Centers 127
TABLE 46 LARGE-CORE SEQUENCING CENTERS 128
Small to Mid-Size Laboratories 129
Sequencing Service Laboratories 129
EARLY ADAPTORS 130
SEQUENCING SAMPLE PREPARATION INDUSTRY 130
SEQUENCE CAPTURE INDUSTRY 131
TABLE 47 POSITIONING OF SEQUENCE CAPTURE FORMATS 131
SAMPLE PREP COMPETITORS 132
TABLE 48 SEQUENCING SAMPLE PREPARATION COMPANY
POSITIONING 133
Sample Prep Competitors (Continued) 134
Sample Prep Competitors (Continued) 135
TABLE 49 PREPARATION FORMATS 136
DIGITAL PCR INDUSTRY 136
TABLE 50 DIGITAL PCR INDUSTRY 137
Digital PCR Industry (Continued) 138
BIOINFORMATICS INDUSTRY 139
TABLE 51 DNA SEQUENCING BIOINFORMATICS COMPANY
POSITIONING 140
PHYSICAL MAPPING 141
TABLE 52 PHYSICAL MAPPING INDUSTRY 142
SEQUENCING SERVICES INDUSTRY 142
TABLE 53 DNA SEQUENCING SERVICES COMPANIES AND
INSTITUTIONS POSITIONING BY MARKET FOCUS 143
CLINICAL SEQUENCING INDUSTRY 144
TABLE 54 LABORATORIES OFFERING NGS CLINICAL
SEQUENCING SERVICES 145
Clinical Sequencing Industry (Continued) 146
Clinical Sequencing Industry (Continued) 147
CONSUMER SEQUENCING INDUSTRY 148
TABLE 55 MEDIUM- TO HIGH-CONTENT CONSUMER GENOMICS
COMPANIES 148
TABLE 55 (CONTINUED) 149
FIGURE 21 PERSONAL GENOMICS COMPETITIVE SPACE BY TEST
COST AND SCOPE 150
TABLE 56 CONSUMER GENOMICS COMPETITOR STRATEGIES ($) 151
AGRICULTURAL GENOMICS INDUSTRY 152
TABLE 57 KEY COMPETITORS IN THE AGRICULTURAL SEED
MARKET 152
AGRICULTURAL GENOMICS INDUSTRY (CONTINUED) 153
SEQUENCING INDUSTRY ACQUISITIONS AND STRATEGIC
ALLIANCES 154
ACQUISITIONS 154
TABLE 58 SEQUENCING INDUSTRY ACQUISITIONS, 2009-2011 154
TABLE 58 (CONTINUED) 155
STRATEGIC ALLIANCES 156
TABLE 59 SEQUENCING INDUSTRY STRATEGIC ALLIANCES, 2009-
2011 157
TABLE 59 (CONTINUED) 158
TABLE 59 (CONTINUED) 159
TABLE 59 (CONTINUED) 160
CLINICAL SEQUENCING ALLIANCES 161
Sequencing Workflow Alliances 162
Sequencing ... (Continued) 163
Sequencing ... (Continued) 164
Emerging Sequencing Technology Alliances 165
Sequencing Market Expansion Alliances 166
Sequencing Market ... (Continued) 167
Sequencing Market ... (Continued) 168
CHAPTER EIGHT: DNA SEQUENCING MARKETS 169
GROWTH DRIVING FORCES 169
TABLE 60 DNA SEQUENCING KEY GROWTH DRIVING FORCES 169
GROWTH DRIVING FORCES (CONTINUED) 170
GROWTH DRIVING FORCES (CONTINUED) 171
SEQUENCING MARKET SUMMARY 172
TABLE 61 GLOBAL VALUE OF THE SEQUENCING MARKET BY
PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 172
SEQUENCING MARKET SUMMARY (CONTINUED) 173
SEQUENCING INSTRUMENTS AND CONSUMABLES MARKETS 174
TABLE 62 GLOBAL VALUE OF THE SEQUENCING INSTRUMENTS
AND CONSUMABLES MARKET BY PRODUCT TYPE, THROUGH
2016 ($ MILLIONS) 174
SEQUENCING INSTRUMENTS AND CONSUMABLES BY
PLATFORM 175
TABLE 63 GLOBAL VALUE OF SEQUENCING INSTRUMENTS BY
PLATFORM, THROUGH 2016 ($ MILLIONS) 175
Sequencing Instruments ...(Continued) 176
TABLE 64 GLOBAL VALUE OF THE SEQUENCING CONSUMABLES
MARKET BY PLATFORM, THROUGH 2016 ($ MILLIONS) 177
NGS INSTRUMENTS AND CONSUMABLES BY PLATFORM 178
TABLE 65 GLOBAL VALUE OF NGS INSTRUMENTS AND
CONSUMABLES BY PLATFORM, THROUGH 2016 ($ MILLIONS) 178
SEQUENCING INSTRUMENTS AND CONSUMABLES BY
END USER 179
TABLE 66 GLOBAL VALUE OF SEQUENCING INSTRUMENTS AND
CONSUMABLES BY CUSTOMER TYPE, THROUGH 2016 ($
MILLIONS) 179
Sequencing Instruments ... (Continued) 180
TABLE 67 GLOBAL VALUE OF SANGER SEQUENCING
INSTRUMENTS AND CONSUMABLES BY CUSTOMER TYPE,
THROUGH 2016 ($ MILLIONS) 181
TABLE 68 GLOBAL VALUE OF NGS SEQUENCING INSTRUMENTS
AND CONSUMABLES BY CUSTOMER TYPE, THROUGH 2016 ($
MILLIONS) 182
TABLE 69 GLOBAL VALUE OF EMERGING SEQUENCING
INSTRUMENTS AND CONSUMABLES BY CUSTOMER TYPE,
THROUGH 2016 ($ MILLIONS) 183
SEQUENCING SAMPLE PREP MARKETS 183
TABLE 70 GLOBAL VALUE OF THE SEQUENCING SAMPLE PREP
MARKET BY APPLICATION, THROUGH 2016 ($ MILLIONS) 184
SEQUENCING BIOINFORMATICS MARKET 185
TABLE 71 GLOBAL VALUE OF THE SEQUENCING
BIOINFORMATICS MARKET BY SOFTWARE FUNCTION,
THROUGH 2016 ($ MILLIONS) 185
SEQUENCING SERVICES MARKETS 186
SEQUENCING SERVICES BY END-USER MARKET 186
TABLE 72 GLOBAL VALUE OF SEQUENCING SERVICES BY ENDUSER
MARKET, THROUGH 2016 ($ MILLIONS) 186
R&D, Pharma and Biotech 187
Consumer Sequencing 188
SEQUENCING SERVICES MARKETS BY TYPE OF
ANALYSIS 189
TABLE 73 GLOBAL VALUE OF SEQUENCING SERVICES BY
ANALYSIS TYPE, THROUGH 2016 ($ MILLIONS) 189
SEQUENCING SERVICES MARKET BY SPECIES 190
TABLE 74 GLOBAL VALUE OF SEQUENCING SERVICES BY
GENOME TYP THROUGH 2016 ($ MILLIONS) 191
APPLIED SEQUENCING SERVICES MARKET 191
TABLE 75 GLOBAL VALUE OF THE APPLIED SEQUENCING
SERVICES MARKET BY APPLICATION, THROUGH 2016 ($
MILLIONS) 191
Applied Sequencing ... (Continued) 192
CLINICAL SEQUENCING SERVICES MARKET 193
Summary 193
TABLE 76 GLOBAL VALUE OF CLINICAL SEQUENCING SERVICES
BY INDICATION, THROUGH 2016 ($ MILLIONS) 194
TABLE 77 GLOBAL VALUE OF CLINICAL SEQUENCING TESTS BY
TECHNOLOGY, THROUGH 2016 ($ MILLIONS) 195
TABLE 78 CLINICAL DIAGNOSTICS PLATFORM COMPARISON 196
Summary (Continued) 197
TABLE 79 STABILIZING MARKET FACTORS FOR SANGER
CLINICAL SEQUENCING 198
Cancer 198
TABLE 80 GLOBAL VALUE OF CLINICAL CANCER SEQUENCING
SERVICES BY INDICATION, THROUGH 2016 ($ MILLIONS) 199
Infectious Diseases 199
TABLE 81 GLOBAL VALUE OF CLINICAL INFECTIOUS DISEASE
SEQUENCING SERVICES BY INDICATION, THROUGH 2016 ($
MILLIONS) 200
Genetic Diseases 201
TABLE 82 GLOBAL VALUE OF CLINICAL GENETIC DISEASE
SEQUENCING SERVICES BY TYPE, THROUGH 2016 ($ MILLIONS) 201
TABLE 83 PRENATAL DIAGNOSTICS TESTS 202
Genetic Diseases (Continued) 203
Immunology 204
TABLE 84 GLOBAL VALUE OF IMMUNOLOGY CLINICAL
SEQUENCING SERVICES BY TYPE, THROUGH 2016 ($ MILLIONS) 205
TABLE 85 HLA TESTING MARKET 206
SEQUENCING MARKETS BY REGION 207
SUMMARY 207
TABLE 86 GLOBAL VALUE OF THE DNA SEQUENCING MARKET BY
REGION, THROUGH 2016 ($ MILLIONS) 208
SEQUENCING INSTRUMENTS AND CONSUMABLES BY
REGION 209
TABLE 87 GLOBAL VALUE OF THE SEQUENCING INSTRUMENT
AND CONSUMABLES MARKET BY REGION, THROUGH 2016 ($
MILLIONS) 209
Sequencing Instruments ...(Continued) 210
TABLE 88 GLOBAL VALUE OF THE SEQUENCING SAMPLE PREP
MARKET BY REGION, THROUGH 2016 ($ MILLIONS) 211
SEQUENCING BIOINFORMATICS MARKET BY REGION 211
TABLE 89 GLOBAL VALUE OF THE SEQUENCING
BIOINFORMATICS MARKET BY REGION, THROUGH 2016 ($
MILLIONS) 212
SEQUENCING SERVICES MARKET BY REGION 212
TABLE 90 GLOBAL VALUE OF THE SEQUENCING SERVICES
MARKET BY REGION, THROUGH 2016 ($ MILLIONS) 212
U S SEQUENCING MARKET 213
TABLE 91 GLOBAL VALUE OF THE U S SEQUENCING MARKET BY
PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 213
GERMANY SEQUENCING MARKET 214
TABLE 92 GLOBAL VALUE OF THE GERMANY SEQUENCING
MARKET BY PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 214
U K SEQUENCING MARKET 215
TABLE 93 GLOBAL VALUE OF THE U K SEQUENCING MARKET BY
PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 215
CHINA SEQUENCING MARKET 216
TABLE 94 GLOBAL VALUE OF THE CHINA SEQUENCING MARKET
BY PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 216
JAPAN SEQUENCING MARKET 216
TABLE 95 GLOBAL VALUE OF THE JAPAN SEQUENCING MARKET
BY PRODUCT TYPE, THROUGH 2016 ($ MILLIONS) 217
CHAPTER NINE: SEQUENCING PATENTS 218
FIGURE 22 SEQUENCING PATENTS, 2001-2011 218
FIGURE 22 (CONTINUED) 219
FIGURE 23 SEQUENCING PATENTS BY REGION, 2001-2011 219
FIGURE 24 EMERGING SEQUENCING COMPANY PATENTS BY
REGION 220
FIGURE 24 (CONTINUED) 221
CHAPTER TEN: COMPANY PROFILES 222
23ANDME INC 222
ACCELRYS INC 223
ADAPTIVE TCR TECHNOLOGIES 223
AGILENT TECHNOLOGIES INC 224
ALTHEADX 225
AMBRY GENETICS 226
ASTRID BIOSCIENCE GMBH 226
ASURAGEN INC 227
AXEQ TECHNOLOGIES 228
BASE4INNOVATION LTD 228
BECKMAN COULTER 229
BGI 230
BGI (CONTINUED) 231
BIO LOGIS GMBH 232
BIOMATTERS LTD 232
BIONANO GENOMICS INC 233
BIOTIQUE SYSTEMS INC 233
BLUESEQ 234
TABLE 96 SEQUENCING MATCHING SERVICE PROVIDERS 235
CAERUS MOLECULAR DIAGNOSTICS 235
CARTAGENIA N V 235
COFACTOR GENOMICS 236
COMPLETE GENOMICS INC 236
CONEXIO GENOMICS 237
CORRELAGEN DIAGNOSTICS INC 238
CUSTOMARRAY INC 238
DANAHER 239
DECODEME 240
DNA ELECTRONICS LTD 241
DNANEXUS INC 241
DNASTAR INC 242
DNA VISION 243
ELECTRONIC BIOSCIENCES 243
ELECTRON OPTICA 244
EUROFINS MEDIGENOMIX GMBH 244
EUROFINS MWG OPERON 245
EXISTENCE GENETICS 246
EXPRESSION ANALYSIS INC 246
FASTERIS SA 247
FIREBIRD BIOMOLECULAR SCIENCES LLC 247
FLUIDIGM CORPORATION 248
FOUNDATION FOR APPLIED MOLECULAR EVOLUTION 249
FOUNDATION MEDICINE 249
GATC BIOTECH AG 250
GE HEALTHCARE 251
GENAPSYS 252
GENDX BV 252
GENEDATA AG 253
GENEDX INC 253
GENIA 254
TABLE 97 COMMERCIAL SEQUENCER COMPETITIVE
POSITIONING 255
GENOMATIX SOFTWARE GMBH 255
GENOMEQUEST INC 256
GENOMIC HEALTH INC 257
GENOVOXX GMBH 258
GEN-PROBE INC 259
GNUBIO INC 259
GOOD START GENETICS INC 260
HALCYON MOLECULAR 261
HALO GENOMICS AB 261
HELICOS BIOSCIENCES CORPORATION 262
INTERNATIONAL BUSINESS MACHINES CORP 263
ILLUMINA INC 264
TABLE 98 ILLUMINA SEQUENCING PORTFOLIO BY INSTRUMENT
($ PER YEAR) 264
INGENUITY SYSTEMS INC 265
INTEGENX 266
INTELLIGENT BIO-SYSTEMS INC 267
INTELLIGENT BIO-SYSTEMS INC (CONTINUED) 268
INTERNA GENOMICS BV 269
IP GENESIS INC 269
IREPERTOIRE 270
ISENTIO AS 271
KEYGENE N V 271
KNOME INC 272
LABORATORY FOR MOLECULAR MEDICINE 273
LASERGEN INC 274
LI-COR BIOSCIENCES 274
LIFECODEXX AG 275
LIFE TECHNOLOGIES INC 276
LINGVITAE HOLDING AS 277
LOCUS DEVELOPMENT INC 278
MACROGEN INC 278
MEDOMICS 279
MOOSBAUM GMBH 279
MYCROARRAY COM 280
NABSYS INC 280
NAVIGENICS INC 281
NETWORK BIOSYSTEMS 282
NEWGENE LTD 282
NOBLEGEN BIOSCIENCES 283
NOVOCRAFT TECHNOLOGIES INC 284
NUGEN TECHNOLOGIES INC 284
OMICIA INC 285
OPGEN INC 286
OXFORD GENE TECHNOLOGY 287
OXFORD NANOPORE TECHNOLOGIES 287
OXFORD NANOPORE ... (CONTINUED) 288
PACIFIC BIOSCIENCES 289
PATHOGENICA 290
PATHOGENETIX 291
PERKINELMER INC 291
PERKINELMER INC (CONTINUED) 292
PERSONALIS 293
POPULATION GENETICS TECHNOLOGIES LTD 293
POPULATION GENETICS ... (CONTINUED) 294
PROGNOSYS BIOSCIENCES INC 295
QIAGEN 296
QUANTALIFE INC 296
QUANTUMDX 297
RAINDANCE TECHNOLOGIES INC 297
TABLE 99 RAINDANCE STRATEGIC ALLIANCES 298
RAINDANCE TECHNOLOGIES INC (CONTINUED) 299
REAL TIME GENOMICS INC 300
ROCHE HOLDING AG 300
ROCHE HOLDING AG (CONTINUED) 301
RUBICON GENOMICS INC 302
SEQUENOM INC 303
SEQUENTA INC 304
SEQWRIGHT 305
SIEMENS AG 305
SLIPCHIP LLC 306
SMARTGENE SERVICES SARL 307
SOURCE BIOSCIENCE PLC 307
SORENSON GENOMICS 308
STRATOS GENOMICS INC 308
SUNDANCE DIAGNOSTICS INC 309
SISTEMAS GENOMICOS 309
THERAGEN ETEX CO LTD 310
TRANSGENOMIC INC 310
TROVAGENE INC 311
VERINATA HEALTH INC 312
WARP DRIVE BIO, LLC 312
X PRIZE FOUNDATION 313
ZS GENETICS 314
ZS GENETICS (CONTINUED) 315
REFERENCES 316
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Genomics Industry: DNA Sequencing: Emerging Technologies and Applications
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